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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 23, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Systemic therapy for bone metastases.

L S Loftus1, S Edwards-Bennett, G H Sokol

  • 1Comprehensive Breast Program, Moffitt Cancer Center, Tampa, FL 33612, USA. Loretta.Loftus@moffitt.org

Cancer Control : Journal of the Moffitt Cancer Center
|April 11, 2012
PubMed
Summary
This summary is machine-generated.

Effective systemic therapies, including bisphosphonates and denosumab, are available to decrease skeletal-related events (SREs) in cancer patients with bone metastases. Research continues to explore novel treatments and optimize current bone-targeted therapies.

Related Experiment Videos

Last Updated: May 23, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Area of Science:

  • Oncology
  • Pharmacology
  • Bone Biology

Background:

  • Cancer-related accelerated bone loss is a significant clinical problem.
  • Bone metastases can lead to a destructive cycle of osteolytic and osteoblastic effects.
  • Skeletal-related events (SREs) like fractures and hypercalcemia complicate cancer treatment.

Purpose of the Study:

  • To review the safety and efficacy of pharmacologic agents for treating bone metastases.
  • To explore antitumor effects of bisphosphonates and the utility of bone turnover markers.
  • To discuss treatment guidelines and economic considerations for bone-targeted therapies.

Main Methods:

  • Systematic literature review of clinical trials.
  • Analysis of pharmacologic agents including bisphosphonates and denosumab.
  • Assessment of medical literature on bone metastases treatment.

Main Results:

  • Developed beneficial systemic therapies reduce SREs in patients with bone metastases.
  • Bisphosphonates show potential antitumor effects.
  • Safety, toxicity, and economic factors of bone-targeted therapies are discussed.

Conclusions:

  • Effective systemic therapies for metastatic bone disease are currently available.
  • Ongoing research aims to further advance treatment options.
  • Future research will continue to refine management of bone metastases.