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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 23, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Tumor microenvironment and lymphocyte infiltration.

Gwendoline Rahir1, Muriel Moser

  • 1Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles, Rue des Pr Jeener et Brachet 12, Gosselies, Belgium. grahir@ulb.ac.be

Cancer Immunology, Immunotherapy : CII
|April 11, 2012
PubMed
Summary
This summary is machine-generated.

Tumor-infiltrating T lymphocytes are crucial for favorable prognoses. Enhancing T cell infiltration into tumors may improve cancer immunotherapy by overcoming immune resistance.

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Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Tumor-infiltrating T lymphocytes (TILs) correlate with better patient prognosis.
  • Effective anti-tumor immunity and immunotherapy may depend on T cell access to the tumor microenvironment.

Purpose of the Study:

  • To review factors influencing T cell infiltration into tumors.
  • To identify potential barriers and facilitators for T cell trafficking in cancer.

Main Methods:

  • Literature review of factors affecting immune cell infiltration.
  • Analysis of tumor microenvironment components influencing T cell migration.

Main Results:

  • Tumor vasculature characteristics can impede or facilitate T cell entry.
  • Chemokine expression and tumor antigen presentation are critical for T cell recruitment.
  • Dendritic cells and CD4+ T lymphocytes play roles in modulating T cell infiltration.

Conclusions:

  • Optimizing T cell infiltration is a key strategy for enhancing cancer immunotherapy.
  • Understanding the tumor microenvironment's influence on T cells is vital for therapeutic development.