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[Transplantable experimental tumor. Morphological and ultrastructural study (author's transl]
L'Ateneo Parmense. Acta Bio-Medica : Organo Della Societa Di Medicina E Scienze Naturali Di Parma
|January 1, 1978
Summary
This study describes an experimental tumor, created using Sendai virus fusion, that was transplanted from chickens to mice. The tumor
Area of Science:
- Oncology
- Virology
- Cell Biology
Context:
- An experimental tumor was induced in newborn chickens via Sendai virus fusion of transformed rat cells and chick embryo cells.
- This tumor was subsequently transplanted into inbred BALB/c mice for further investigation.
Purpose:
- To characterize the histological and ultrastructural features of an experimentally induced tumor.
- To compare the tumor's morphology in chicken and mouse hosts with known sarcoma patterns.
Summary:
- The experimental tumor, derived from Sendai virus-mediated fusion, exhibited anaplastic fibrosarcoma-like characteristics in both chicken and mouse models.
- Microscopic analysis revealed distinct differences compared to Rous sarcoma and a spontaneous BALB/c mouse rhabdomyosarcoma.
- Tumor malignancy was assessed based on its rapid growth potential.
Impact:
- Provides a comparative morphological analysis of a xenografted experimental tumor.
- Contributes to understanding tumor behavior and histological classification across different hosts.
- Highlights the utility of this model for studying fibrosarcoma-like neoplasms.