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Updated: May 23, 2026
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 20, 2009
[Clinical safety about repairing the peripheral nerve defects with chemically extracted acellular nerve allograft]
Run-gong Yang1, Hong-bin Zhong, Jia-liang Zhu
1Department of Orthopedics, the First Affiliated Hospital of General Hospital of People's Liberation Army, Beijing 100048, China. yangrg304@tom.com
Objective:
To discuss the clinical safety about repairing the peripheral nerve defects with the acellular allogeneic nerve.
Methods:
The 41 patients (male 38, female 3, age 10 - 55 years old, average 28.9 years old) who were performed chemically extracted acellular nerve allograft transplanting to repair nerve defects from 2002 to 2011. The average interval from injury to nerve repairing was 4.1 months (range, 10 hours to 9 months). There were 41 cases nerve defects including 10 brachial plexus nerves, 3 radial nerves of upper arm, 4 ulnar nerves of forearm, 12 digital and toe nerves, 2 sciatic nerves, 2 femoral nerves, 3 tibial nerves and 5 common peroneal nerves. There were 12 cases combined fractures and 20 soft tissue injury or defects. The average length of the nerve allograft to bridge the nerve defects was 6.1 cm (range, 2 - 10 cm). No immunosuppressive drugs were used in all cases. The clinical safety was evaluated through physical examination, blood biochemistry and immunity detection.
Results:
All cases were followed up post-operation. They got primary wound healing except 2 superficial infection who got delay healing through dressings changing. No any adverse effects happened including immunological rejection, hypersensitivity reaction, deep infection, hepatotoxicity and nephrotoxicity.
Conclusions:
It is safe and feasible to repairing human peripheral nerve defects with chemically extracted acellular nerve allograft.
