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Effects of lubricants on binary direct compression mixtures.
T Uğurlu1, M D Halaçoğlu, M Türkoğlu
1Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Haydarpa ş a, Istanbul, Turkey.
Drug Discoveries & Therapeutics
|April 12, 2012
Summary
Hexagonal boron nitride (HBN) is as effective as magnesium stearate (MGST) in direct compression tablet manufacturing, showing no significant negative impact on tablet strength. Other lubricants like stearic acid (STAC) and glyceryl behenate (COMP) were less effective.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Direct compression is a common tablet manufacturing method.
- Lubricants are crucial for preventing sticking and ensuring tablet ejection.
- Evaluating new lubricants is essential for optimizing tablet formulations.
Purpose of the Study:
- To investigate the impact of four lubricants (magnesium stearate, stearic acid, glyceryl behenate, hexagonal boron nitride) on binary direct compression mixtures.
- To compare the effectiveness of these lubricants and their effect on tablet crushing strength.
Main Methods:
- Binary mixtures of spray dried lactose, dicalcium phosphate dihydrate, and modified starch with microcrystalline cellulose were prepared.
- Tablets were manufactured using a single-station tablet press with varying lubricant concentrations (0.5-4%).
- Tablet crushing strength was measured, and data were analyzed using factorial ANOVA.
Main Results:
- Unlubricated modified starch-microcrystalline cellulose mixtures showed the highest compressibility.
- Hexagonal boron nitride (HBN) demonstrated lubricant effectiveness comparable to magnesium stearate (MGST) without significantly compromising tablet crushing strength.
- Stearic acid (STAC) and glyceryl behenate (COMP) were less effective lubricants and showed a linear decline in crushing strength with increasing concentration.
Conclusions:
- Hexagonal boron nitride (HBN) is a viable alternative lubricant for direct compression, offering similar efficacy to magnesium stearate (MGST).
- The choice of lubricant and its concentration significantly impacts tablet properties, particularly crushing strength.
- Formulation composition influences lubricant sensitivity, with some mixtures being more affected than others.
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