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Related Experiment Video

Updated: May 23, 2026

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
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Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Baseline cardiovascular risk predicts subsequent changes in resting brain function.

Lori L Beason-Held1, Madhav Thambisetty, Gerard Deib

  • 1Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. heldlo@mail.nih.gov

Stroke
|April 12, 2012
PubMed
Summary
This summary is machine-generated.

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Higher cardiovascular disease risk in older adults is linked to faster declines in brain blood flow, particularly in areas vital for cognitive function. Managing risk factors like blood pressure and diabetes is crucial for brain health.

Area of Science:

  • Neuroscience
  • Cardiology
  • Gerontology

Background:

  • Cardiovascular disease risk factors are prevalent in aging populations.
  • Cognitive decline is a significant concern in older adults.

Purpose of the Study:

  • To investigate the association between cardiovascular disease risk and changes in resting-state cerebral blood flow (CBF).
  • To examine how baseline cardiovascular risk impacts longitudinal CBF in cognitively normal older adults.

Main Methods:

  • Utilized positron emission tomography (PET) scans to quantify regional CBF over 8 years in 97 participants.
  • Calculated voxel-wise longitudinal rates of CBF change.
  • Correlated baseline Framingham Heart Study group cardiovascular risk profile (FCRP) scores and individual risk factors with CBF changes.

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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Related Experiment Videos

Last Updated: May 23, 2026

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
05:23

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Main Results:

  • Higher baseline FCRP scores correlated with accelerated CBF decline in key brain regions (orbitofrontal, medial frontal/anterior cingulate, insular, precuneus, brain stem).
  • Elevated diastolic blood pressure and diabetes independently predicted greater CBF decline in specific regions.

Conclusions:

  • Baseline cardiovascular risk is associated with accelerated decline in resting-state regional brain function.
  • Affected brain regions are critical for higher-order cognition and vulnerable to age-related changes.
  • Early management of cardiovascular risk factors is recommended to preserve brain function in older individuals.