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Related Experiment Video

Updated: May 23, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Atherogenic effect of Arecoline: A computational study.

Manabendra Dutta Choudhury, Pankaj Chetia, Karabi Dutta Choudhury

    Bioinformation
    |April 12, 2012
    PubMed
    Summary

    Arecoline, found in areca nut, may increase stroke risk by blocking LDL and HDL receptors, potentially contributing to atherosclerosis. This study suggests a link between betel quid chewing and cerebrovascular disease.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cardiovascular Research

    Background:

    • Areca nut chewing is prevalent in Asia, with arecoline identified as a key constituent.
    • Arecoline is linked to oral cancer, but its role in cerebrovascular disease is less understood.
    • Clinical observations in betel quid-chewing regions suggest a potential link to stroke.

    Purpose of the Study:

    • To investigate the interaction between arecoline and Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) receptors.
    • To explore the molecular mechanisms by which arecoline might influence cardiovascular health.
    • To assess the potential of arecoline to contribute to cerebrovascular disease through receptor interactions.

    Main Methods:

    • Computational tools were used to study ligand-target interactions.
    Keywords:
    ArecolineAtherogenic effectCerebro Vascular DiseaseHDL receptorInsilicoLDL receptor

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    Last Updated: May 23, 2026

    Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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  • Molecular docking was performed to analyze the binding affinity of arecoline with human LDL receptor and bovine HDL receptor.
  • Cholesterol and a control compound (thiosemicarbazone) were used for comparative analysis.

    • Main Results:

    • Arecoline demonstrated a significantly higher binding affinity to the human LDL receptor extracellular domain than cholesterol.
    • Arecoline showed potential to block the bovine HDL receptor, although with less potency than the control compound.
    • The binding interactions suggest arecoline interferes with normal cholesterol transport mechanisms.

    Conclusions:

    • Arecoline may contribute to atherosclerosis by inhibiting LDL cholesterol endocytosis and interfering with hepatic LDL uptake via HDL receptor interaction.
    • The findings suggest a plausible molecular basis for the observed correlation between betel quid consumption and cerebrovascular disease.
    • Further research is warranted to confirm these in silico findings and explore therapeutic interventions.