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Related Experiment Video

Updated: May 23, 2026

Behavioral Characterization of an Angelman Syndrome Mouse Model

Behavioral Characterization of an Angelman Syndrome Mouse Model

Published on: October 20, 2023

Functional analysis and functional communication training in individuals with Angelman syndrome.

Maartje Radstaake¹, Robert Didden, Christopher Oliver

¹Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands. m.radstaake@pwo.ru.nl

Developmental Neurorehabilitation

|April 13, 2012

Summary

Functional communication training (FCT) effectively reduced challenging behaviors in children with Angelman syndrome (AS) by targeting precursors. This approach identified behavioral functions and promoted communication equivalence.

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Area of Science:

Behavioral science
Developmental psychology
Genetics

Background:

Angelman syndrome (AS) is a genetic disorder associated with significant developmental delays and challenging behaviors.
Understanding the function of these behaviors is crucial for effective intervention.
Previous research has explored interventions for AS, but further investigation into precursor-based strategies is warranted.

Purpose of the Study:

To determine the functions of challenging behaviors in four children diagnosed with Angelman syndrome.
To evaluate the efficacy of functional communication training (FCT) combined with precursor-based prompting.
To extend previous findings on behavioral interventions for Angelman syndrome.

Main Methods:

Experimental functional analysis was employed to identify the underlying causes of challenging behaviors.
Functional communication training (FCT) was implemented using an ABAB research design.
Burst analyses were conducted to examine precursor behaviors preceding target challenging behaviors, and effect sizes were calculated.

Main Results:

Challenging behaviors were found to serve functions related to attention, tangible reinforcement, or escape from demands.
Precursor behaviors, such as physical contact, eye contact, and reaching for items, were identified.
Functional communication training (FCT) demonstrated effects ranging from small to large in reducing challenging behaviors.

Conclusions:

The study successfully identified the behavioral functions of challenging behaviors in children with AS.
FCT, when initiated based on precursor behaviors, proved effective in decreasing the frequency of challenging behaviors.
A functional equivalence was established between challenging behaviors and communicative actions, supporting the use of precursor-based interventions.