Related Experiment Video

Updated: May 23, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
09:11

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

Advances in cell-based therapy for peripheral vascular disease

Arnon Blum1, Wayne Balkan, Joshua M Hare

  • 1Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136 USA.

Atherosclerosis
|April 13, 2012
PubMed

Insights

Cell transplantation shows promise for treating chronic cardiovascular diseases like peripheral vascular disease. Clinical trials indicate progenitor cells effectively promote blood vessel repair, suggesting a new therapeutic avenue.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Cellular Therapeutics

Background:

  • Cell-based therapies are emerging as a significant treatment approach for chronic diseases.
  • Cardiovascular disorders represent a major area of impact due to high patient numbers.
  • Peripheral vascular disease, including ischemic stroke and erectile dysfunction, is a key focus.

Purpose of the Study:

  • To review published clinical studies on cell transplantation for peripheral vascular ischemic disorders.
  • To evaluate the efficacy of cell transplantation in treating conditions like peripheral artery disease.
  • To discuss the role of bone marrow-derived cells in endogenous repair and angiogenesis.

Main Methods:

  • Review of published clinical studies and registered clinical trials (ClinicalTrials.gov).
  • Analysis of cell transplantation approaches for peripheral vascular disease.
  • Examination of progenitor cells from monocytic and non-monocytic sources.

Main Results:

  • Bone marrow-derived cells are crucial for endogenous repair in angiopathies.
  • Progenitor cells from both monocytic and non-monocytic sources show effectiveness.
  • Angiogenesis appears to result from intercellular communication and pathway interactions.

Conclusions:

  • Cell transplantation is a potential therapeutic strategy for peripheral vascular disease.
  • Ongoing clinical trials are investigating stem cell therapy for peripheral artery disease.
  • The findings support further research into cell-based treatments for ischemic disorders.

More Related Videos

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits07:34

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...