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Updated: May 23, 2026

High Precision Zinc Isotopic Measurements Applied to Mouse Organs
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Very high specific activity ⁶⁶/⁶⁸Ga from zinc targets for PET.

J W Engle1, V Lopez-Rodriguez, R E Gaspar-Carcamo

  • 1Department of Medical Physics, University of Wisconsin, B1303 WIMR Cyclotron Labs, 1111 Highland Avenue, Madison, WI 53705, USA. engle.jonathan@gmail.com

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|April 13, 2012
PubMed
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This study details the production of high specific activity Gallium-66 (66Ga) using proton irradiation of zinc targets. Optimized methods yield highly reactive 66Ga suitable for radiolabeling applications.

Area of Science:

  • Radiochemistry
  • Nuclear Medicine
  • Isotope Production

Background:

  • Gallium-66 (66Ga) is a positron-emitting radionuclide with potential applications in nuclear medicine.
  • Efficient production of high specific activity 66Ga is crucial for its use with bifunctional chelates in radiopharmaceuticals.

Purpose of the Study:

  • To describe the production of very high specific activity (66/68)Ga from natural and enriched zinc targets.
  • To optimize the production and purification of 66Ga for radiolabeling applications.

Main Methods:

  • Proton irradiations of natural zinc (nat)Zn and enriched (66)Zn targets using proton energies between 7 and 16 MeV.
  • Cation exchange chromatography in hydrochloric acid solution for radiogallium separation.
  • Inductively coupled plasma mass spectroscopy (ICP-MS) for impurity analysis.

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Main Results:

  • Production of high specific activity 66Ga achieved from (nat)Zn(p,n) and (66)Zn(p,n) reactions.
  • Radiogallium separated from target material using cation exchange chromatography.
  • Radio-gallium reactivity with common bifunctional chelates reached 740 GBq/micromol using natural zinc targets.
  • Less than 2 ppb non-radioactive gallium detected in the final product via ICP-MS.

Conclusions:

  • The described methods enable the efficient production of high specific activity 66Ga suitable for radiolabeling.
  • Recycling of zinc target material is possible but not essential for achieving high specific activity.
  • The high reactivity of 66Ga supports its use in developing novel diagnostic and therapeutic radiopharmaceuticals.