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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: May 23, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Behçet's disease.

David Saadoun1, Bertrand Wechsler

  • 1Service de Médecine Interne 2, Centre de Référence Maladies Autoimmunes rares, CHU Pitié-Salpêtrière, 83 Bd de l'Hôpital, 75013, Paris, France. david.saadoun@psl.aphp.fr

Orphanet Journal of Rare Diseases
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

Behçet disease (BD) is a chronic multisystem disorder with varied manifestations. Early symptomatic treatment with steroids and immunomodulatory therapy improves outcomes, but prognosis remains severe due to potential ocular, neurological, and arterial involvement.

Related Experiment Videos

Last Updated: May 23, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Behçet disease (BD) is a chronic, relapsing, multisystemic disorder.
  • It is characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations.
  • The disease prevalence clusters along the ancient Silk Road, with cases reported in Europe, particularly among migrant populations.

Purpose of the Study:

  • To define Behçet disease (BD).
  • To outline its clinical spectrum, diagnostic criteria, and management.
  • To discuss the prognosis associated with BD.

Main Methods:

  • Diagnosis of BD relies solely on clinical criteria.
  • Differential diagnosis involves considering conditions such as sarcoidosis, multiple sclerosis, Crohn's disease, Takayasu's arteritis, polychondritis, and antiphospholipid syndrome.

Main Results:

  • The clinical spectrum of BD encompasses oral and genital ulcerations, uveitis, and vascular, neurological, articular, renal, and gastrointestinal manifestations.
  • Symptomatic treatment using steroids and immunomodulatory therapy is employed.
  • Treatment efficacy is contingent upon the promptness of initiation, patient compliance, and therapy duration.

Conclusions:

  • The prognosis for Behçet disease (BD) is considered severe.
  • This severity is primarily attributed to potential ocular, neurological, and arterial involvement.