Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 23, 2026

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Humanizing thrombi in mice.

Jorge Magallon¹, Matthew Egalka, Thomas G Diacovo

¹Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

Trends in Cardiovascular Medicine

|April 14, 2012

Summary

Developing novel antiplatelet therapies requires better predictive models. A unique genetically modified animal model shows promise for accurately predicting human responses to antiplatelet agents, improving cardiovascular disease prevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preclinical Efficacy of a Hemostatic Agent in Overcoming Dual Antiplatelet Therapy.

JACC. Basic to translational science·2025

Same author

General Anesthesia and the Premature Baby: Identifying Risks for Poor Neurodevelopmental Outcomes.

Journal of neurosurgical anesthesiology·2023

Same author

Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis.

JCI insight·2019

Same author

Outcomes Research in Vulnerable Pediatric Populations.

Journal of neurosurgical anesthesiology·2019

Same author

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Proceedings of the National Academy of Sciences of the United States of America·2018

Same author

P2Y<sub>12</sub> Receptor Function and Response to Cangrelor in Neonates With Cyanotic Congenital Heart Disease.

JACC. Basic to translational science·2017

Area of Science:

Pharmacology
Cardiovascular Disease
Translational Medicine

Background:

Antiplatelet therapies are crucial for preventing atherothrombosis and reducing cardiovascular disease (CVD) morbidity and mortality.
Current drug development faces challenges due to limitations in existing animal models for predicting human responses.
There is a significant unmet need for more effective and safer antiplatelet agents.

Purpose of the Study:

To introduce and evaluate a unique genetically modified animal model for predicting in vivo responses to antiplatelet agents.
To demonstrate the model's potential to improve the accuracy of antiplatelet drug development compared to conventional murine models.

Main Methods:

Utilized a unique genetically modified animal model designed to better mimic the human intravascular environment.

More Related Videos

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Related Experiment Videos

Last Updated: May 23, 2026

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Assessed the predictive accuracy of this model for in vivo responses to various antiplatelet therapies.

Main Results:

The genetically modified animal model demonstrated enhanced accuracy in predicting human in vivo responses to antiplatelet agents.
This model offers a more reliable platform for evaluating drug efficacy and safety.

Conclusions:

The developed genetically modified animal model represents a significant advancement in preclinical testing for antiplatelet therapies.
This platform can accelerate drug development, optimize dosing, and improve clinical study design for cardiovascular disease prevention.