Related Experiment Video
Updated: May 23, 2026
08:13
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Coronary surgery in a hemophiliac with continuous factor VIII replacement
Alan P Kypson1, Evelio Rodriguez, Curtis A Anderson
1Division of Cardiothoracic Surgery, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, 600 Moye Blvd, Greenville, NC 27834, USA. kypsona@ecu.edu
Asian Cardiovascular & Thoracic Annals
|April 14, 2012
Summary
Hemophiliacs now live longer, facing age-related conditions like coronary atherosclerosis. This case study details the successful hematologic management for a hemophilia A patient undergoing coronary artery bypass surgery.
Area of Science:
- Cardiology
- Hematology
- Vascular Surgery
Background:
- Historically, hemophilia limited patient lifespan, precluding cardiac surgery.
- Advances in blood transfusion safety have increased longevity for hemophiliacs.
- Longer lifespans increase susceptibility to age-related cardiovascular diseases, including coronary atherosclerosis.
Observation:
- A patient with hemophilia A presented with coronary atherosclerosis.
- The patient required coronary artery bypass surgery.
Findings:
- Successful perioperative hematologic management was achieved for a hemophilia A patient undergoing coronary artery bypass surgery.
- This involved meticulous management of clotting factors and blood products.
Implications:
- This case demonstrates the feasibility of complex cardiac procedures in hemophiliacs.
- Improved hematologic strategies can enhance outcomes for hemophiliacs with cardiovascular disease.
- Highlights the evolving care paradigms for patients with inherited bleeding disorders.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
01:30Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...