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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Exercise and Cardiovascular Response01:20

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Related Experiment Video

Updated: May 23, 2026

Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
07:52

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Published on: August 14, 2014

Exercise, inflammation and aging.

Jeffrey A Woods1, Kenneth R Wilund, Stephen A Martin

  • 1Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, Urbana IL, 61801, USA.

Aging and Disease
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

Regular exercise may reduce chronic inflammation in older adults, improving health and quality of life. This review examines clinical trials on exercise

Keywords:
AdiposeAgingElderlyExercise, Inflammation

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Area of Science:

  • Gerontology and Exercise Science
  • Inflammation and Aging Research

Background:

  • Aging is characterized by chronic, low-grade inflammation, increasing disease risk and mortality.
  • Strategies to mitigate age-related inflammation are crucial for enhancing well-being in older adults.
  • While exercise offers numerous health benefits, its anti-inflammatory effects in the elderly are a recent focus of research.

Purpose of the Study:

  • To review randomized clinical trial evidence on the impact of exercise training on inflammatory biomarkers in the elderly.
  • To explore potential mechanisms underlying the anti-inflammatory effects of exercise in older populations.

Main Methods:

  • Systematic review of randomized clinical trials (RCTs).
  • Analysis of studies investigating the effects of exercise interventions on inflammatory markers in elderly participants.
  • Examination of proposed biological pathways linking exercise to reduced inflammation.

Main Results:

  • Exercise training demonstrates a significant influence on inflammatory biomarkers in older adults.
  • Evidence suggests that regular physical activity can modulate key inflammatory pathways associated with aging.
  • Specific exercise modalities and intensities may yield varying anti-inflammatory outcomes.

Conclusions:

  • Exercise training is a viable strategy to combat age-related inflammation.
  • Understanding the mechanisms can inform targeted exercise prescriptions for healthier aging.
  • Further research is warranted to optimize exercise interventions for maximal anti-inflammatory benefits in the elderly.