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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: May 23, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Disability in inflammatory bowel disease.

Bincy P Abraham1, Joseph H Sellin

  • 1Section of Gastroenterology and Hepatology, Baylor College of Medicine, 1709 Dryden Street, Suite 800, Houston, TX 77030, USA. bincya@bcm.edu

Gastroenterology Clinics of North America
|April 17, 2012
PubMed
Summary
This summary is machine-generated.

Disability significantly impacts Inflammatory Bowel Disease (IBD) patients, affecting quality of life and incurring societal costs. A new tool may help assess varied disease effects and guide treatment considerations to reduce these indirect economic burdens.

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Area of Science:

  • Gastroenterology and Patient-Reported Outcomes

Background:

  • Disability in Inflammatory Bowel Disease (IBD) encompasses physical, psychosocial, and employment aspects, impacting patient quality of life.
  • IBD-related disability leads to significant indirect societal costs, including workforce loss and increased absenteeism.

Purpose of the Study:

  • To highlight the economic impact of disability in IBD patients.
  • To introduce a novel tool for assessing disease severity and its varied effects.
  • To inform treatment considerations by evaluating potential reductions in indirect costs.

Main Methods:

  • Development and validation of a new assessment tool for IBD-related disability.
  • Analysis of indirect costs associated with IBD patient disability.
  • Evaluation of the tool's utility in establishing disease-specific criteria.

Main Results:

  • Disability in IBD patients results in substantial indirect costs to individuals and society.
  • The newly developed tool shows promise in characterizing the multifaceted nature of IBD disability.
  • The tool can aid in setting criteria for diseases with heterogeneous presentations and severity.

Conclusions:

  • Addressing disability in IBD is crucial for improving patient well-being and reducing societal economic burdens.
  • The developed tool offers a standardized approach to evaluating IBD-related disability.
  • This tool can support informed decision-making regarding treatment strategies aimed at mitigating indirect costs.