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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
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Anxiety and depression in various functional gastrointestinal disorders: do differences exist?

Juanda Leo Hartono1, Sanjiv Mahadeva, Khean-Lee Goh

  • 1Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Journal of Digestive Diseases
|April 17, 2012
PubMed
Summary

Anxiety and depression are more prevalent in patients with functional gastrointestinal disorders (FGIDs) like functional dyspepsia (FD), nonerosive reflux disease (NERD), and irritable bowel syndrome (IBS) compared to healthy individuals. Irritable bowel syndrome (IBS) showed a higher anxiety rate.

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Area of Science:

  • Gastroenterology
  • Psychiatry
  • Clinical Psychology

Background:

  • Functional gastrointestinal disorders (FGIDs) such as functional dyspepsia (FD), nonerosive reflux disease (NERD), and irritable bowel syndrome (IBS) are common conditions.
  • The interplay between FGIDs and psychological distress, particularly anxiety and depression, is an area of ongoing research.

Purpose of the Study:

  • To investigate and compare the prevalence and severity of anxiety and depression among patients diagnosed with FD, NERD, IBS, and healthy controls.
  • To explore potential differences in psychological comorbidities across these FGID subtypes.

Main Methods:

  • A cohort of 248 patients undergoing endoscopic examination for various symptoms were recruited and categorized into FD, NERD, IBS, and control groups (62 each).
  • Diagnosis of FGIDs was based on the Rome III criteria.
  • Anxiety and depression levels were assessed using a validated Hospital Anxiety and Depression Scale.

Main Results:

  • Patients with FD, NERD, and IBS exhibited significantly higher prevalence rates of both anxiety and depression compared to the healthy control group.
  • Specifically, anxiety prevalence was 43.5% (FD), 45.2% (NERD), and 67.7% (IBS) versus 14.5% in controls (P<0.001).
  • Depression prevalence was 22.6% (FD), 33.9% (NERD), and 38.7% (IBS) versus 6.5% in controls (P<0.0001).
  • Irritable bowel syndrome (IBS) patients demonstrated a higher rate of anxiety compared to both FD (P=0.01) and NERD (P=0.02) patients.
  • No significant differences in depression rates were found among the three FGID groups.

Conclusions:

  • Anxiety appears to be more prevalent in patients with irritable bowel syndrome (IBS) than in those with functional dyspepsia (FD) or nonerosive reflux disease (NERD).
  • The findings suggest a potential causal relationship between anxiety and IBS.
  • Further research is warranted to elucidate the complex bidirectional relationship between FGIDs and mental health conditions.