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Updated: May 23, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Tracer kinetics and metabolic models in medicine
Peter Junghans1, Barbara Wagner, Andreas Nickel
1Central Institute for Isotope and Radiation Research, Academy of Sciences of the GDR, Leipzig, Germany. junghans@fbn-dummerstorf.de
Abstract:
In the present paper, a survey of methods applied to the interpretation and evaluation of tracer kinetic data is given. For their mathematical description, both compartmental and non-compartmental models, such as the modified model of Sprinson and Rittenberg, the San Pietro-Rittenberg model, two models of the albumin metabolism and a 10-pool model of the N and protein metabolism were used. By means of single or multiple pulse, infusion and priming techniques, the N and protein metabolism in various metabolic states (e.g. healthy man, pathological and stress conditions, therapeutic treatments) were studied.
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