Related Experiment Video
Updated: May 23, 2026
05:59
High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
Published on: October 20, 2023
Insomnia in Cornelia de Lange syndrome
Roy Rajan1, James R Benke, Antonie D Kline
1Emory University, Department of Otolaryngology - Head and Neck Surgery, 1365 Clifton Road NE, Building A - Suite 2300, Atlanta, GA 30322, United States.
International Journal of Pediatric Otorhinolaryngology
|April 17, 2012
Summary
Sleep disturbances, including insomnia and circadian rhythm issues, are common in Cornelia de Lange Syndrome (CdLS). This study screened 31 CdLS patients, finding significant sleep problems in both children and adults.
Area of Science:
- Genetics and Rare Diseases
- Sleep Medicine
- Pediatric Neurology
Background:
- Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder associated with significant health challenges.
- Sleep disturbances affect up to 55% of individuals with CdLS.
- Previous research suggests a link between sleep issues and intellectual disability or self-injurious behavior in non-CdLS populations.
Purpose of the Study:
- To investigate the prevalence and characteristics of sleep disturbances in individuals with CdLS.
- To screen for symptoms indicative of insomnia and circadian rhythm disorders in a cohort of CdLS patients.
- To explore potential differences in sleep patterns between pediatric and adult CdLS populations.
Main Methods:
- A sleep history questionnaire was administered to caregivers of 31 patients (19 children, 12 adults) with CdLS.
- The questionnaire focused on sleep patterns and evening sleep behaviors.
- Data was collected to screen for signs and symptoms of insomnia and circadian rhythm disorders.
Main Results:
- Major difficulties in falling asleep (75% pediatric, 33% adult) and staying asleep (52% pediatric, 33% adult) were reported.
- Average time to sleep onset was 27 minutes, increasing to 37.8 minutes for those with stated difficulty.
- Pediatric patients experienced more nighttime awakenings (1.5) compared to adults (0.7), and took longer to fall back asleep (61.8 min vs. 14.9 min).
Conclusions:
- Symptoms suggestive of insomnia or circadian rhythm disorders are prevalent in individuals with CdLS.
- Adults with CdLS may experience less severe sleep disturbances than children, though further research is needed.
- Characterizing sleep disturbances in CdLS is crucial for improving patient care and quality of life.
More Related Videos
04:33Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
Related Concept Videos
01:19Management of Insomnia
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
01:27Insomnia
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
01:07Narcolepsy
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
01:24Sleep-Wake Cycles
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
01:27Restless Leg Syndrome and Night Terrors
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
01:15REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...