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Updated: May 23, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Micro-RNAs: New Regulators of Wound Healing

Irena Pastar1, Horacio Ramirez2, Olivera Stojadinovic3

  • 1Research Assistant Professor, Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of, Miami Miller School of Medicine, Miami, Florida.

Surgical Technology International
|April 17, 2012
PubMed

Insights

MicroRNAs (miRNAs) are key gene regulators. This review explores their role in chronic wound healing, suggesting potential as diagnostic and therapeutic targets for better patient outcomes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Chronic wounds pose a significant clinical and economic burden.
  • MicroRNAs (miRNAs) are critical regulators of gene expression involved in numerous biological processes.
  • The specific role of miRNAs in chronic wound pathogenesis is not fully understood.

Purpose of the Study:

  • To review the existing literature on the function of miRNAs in wound healing.
  • To explore the potential involvement of miRNAs in the pathology of chronic wounds.
  • To discuss the prospective use of miRNAs in diagnostics and therapeutics for chronic wounds.

Main Methods:

  • Comprehensive literature review of studies investigating miRNAs and wound healing.
  • Analysis of miRNA involvement in epidermal differentiation, proliferation, inflammation, and angiogenesis.
  • Synthesis of current knowledge regarding miRNA dysregulation in chronic wounds.

Main Results:

  • miRNAs regulate key processes essential for normal wound healing, including cellular differentiation, proliferation, inflammation, and blood vessel formation.
  • Aberrant miRNA expression is implicated in the development and persistence of chronic wounds.
  • miRNAs show promise as biomarkers for assessing debridement needs and as therapeutic targets.

Conclusions:

  • miRNAs play a crucial role in both normal and pathological wound healing processes.
  • Understanding miRNA functions offers new avenues for diagnosing and treating chronic wounds.
  • miRNAs represent a promising frontier for novel therapeutic strategies in wound care.

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