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Updated: May 23, 2026
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus
Kichul Ko1, Beverly S Franek, Miranda Marion
1Section of Rheumatology, Gwen Knapp Center for Lupus Research, University of Chicago, Chicago, IL 60637, USA.
Objective:
To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds.
Methods:
We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry.
Results:
African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10(-5)).
Conclusion:
Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α.
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