Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subcortical volumetric reductions in adult Niemann-Pick disease type C: a cross-sectional study.

AJNR. American journal of neuroradiologyยท2012
Same author

The mechanism of oscillopsia and its suppression.

Annals of the New York Academy of Sciencesยท2011
Same author

Effects of acetazolamide on infantile nystagmus syndrome waveforms: comparisons to contact lenses and convergence in a well-studied subject.

The open ophthalmology journalยท2011
Same author

Extending the eXpanded Nystagmus Acuity Function for vertical and multiplanar data.

Vision researchยท2009
Same author

Saccades in adult Niemann-Pick disease type C reflect frontal, brainstem, and biochemical deficits.

Neurologyยท2009
Same author

Factors influencing pursuit ability in infantile nystagmus syndrome: Target timing and foveation capability.

Vision researchยท2008

Related Experiment Video

Updated: May 23, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

Variable waveforms in downbeat nystagmus imply short-term gain changes.

L A Abel1, S Traccis, L F Dell'Osso

  • 1Ocular Motor Neurophysiology Laboratory, Veterans Administration Medical Center, Cleveland, OH, USA.

Annals of Neurology
|April 18, 2012
PubMed
Summary

This study examines downbeat nystagmus in a patient with ankylosing spondylitis, revealing varied slow-phase waveforms. Findings suggest cerebellar gain changes may explain these complex nystagmus patterns.

More Related Videos

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems
08:38

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems

Published on: April 18, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems
08:38

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems

Published on: April 18, 2019

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Rheumatology

Background:

  • Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine.
  • Downbeat nystagmus is an involuntary eye movement characterized by a downward drift.
  • The neural mechanisms underlying nystagmus waveforms are not fully understood.

Observation:

  • A patient with ankylosing spondylitis presented with downbeat nystagmus.
  • The nystagmus exhibited increasing- and decreasing-velocity exponential slow phases, alongside the commonly reported linear form.
  • Waveform alternations occurred on beat-to-beat or intrabeat bases.

Findings:

  • The study proposes short-term gain changes in cerebellar compensation for leaky brainstem neural integrators as an explanation for the observed waveforms.
  • A computer model was developed to simulate and analyze these proposed mechanisms.
  • The findings highlight the complex interplay between cerebellar function and neural integrators in generating nystagmus.

Implications:

  • Understanding these mechanisms can lead to improved diagnostic approaches for nystagmus.
  • This research may inform the development of targeted therapies for nystagmus associated with neurological or inflammatory conditions.
  • The study contributes to the broader understanding of gaze stabilization and neural control of eye movements.