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Published on: June 14, 2015
[Effects of CVB-D on hemodynamic in anaesthetized dogs in vivo]
Bin Yu1, Ming Ruan, Xiang-Chun Shen
1Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of TCM, Nanjing 200046, China. yubinruming@sina.com
Objective:
To investigate hemodynamic in anaesthetized dogs after the intravenous injection of cyclovirobuxine D (CVB-D).
Methods:
The hemodynamic of anaesthetized dogs were observed after intravenous injection of CVB-D at doses of 0.1, 0.2, 0.4 mg/kg.
Results:
CVB-D of 0.2 and 0.4 mg/kg could decrease HR, TPVR and increase CBF. In addition, CVB-D of 0.4 mg/kg could increase SAP and SV. Yet MAP and CO of dogs showed no remarkable changes with the treatment of CVB-D.
Conclusion:
CVB-D has effect of improving cardiac function, which may be the mechanism of anti-myocardial ischemia effect of CVB-D.
