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Updated: May 23, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
[Preparation of curcumin solid dispersion and inclusion complex]
Zhen-Shen Gao1, Xiao-Li Zhang, Jian-Duo Wang
1College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn
Objective:
To prepare the curcumin solid dispersion and the curcumin inclusion complex, evaluate its stability and the transdermal properties.
Methods:
The samples were prepared with hydrophilic, or water-soluble polymers, by solvent and solvent-melting methods. The optical microscope and the melting point were used to identify the state of the drug existence in it, and UV-Vis spectrophotometer was used to determine the solubility and content of different samples. They were placed under conditions of light, phosphate buffers with different pH values and different metal ions to determine their stability. The lipid/aqueous partition coefficients and the permeation of samples were measured.
Results:
The content and solubility of curcumin in the solid dispersion prepared with PVP k-30 as the carrier were larger than those of other solid dispersions, with 81.26% and 337.59 microg/mL, respectively. The oil-water distribution coefficient was 26.04, indicating good penetration properties.
Conclusion:
The solubilty and stability of curcumin can be improved to various degrees. The solubility and oil-water partition coefficient of the curcumin solid dispersion prepared by povidone k-30 as a carrier is the largest.
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