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Updated: May 23, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy
Todd C Rideout1, Scott V Harding, Dylan S Mackay
1Department of Exercise and Nutrition Sciences, University at Buffalo, NY 14214, USA. rideout@buffalo.edu
Abstract:
Reducing intestinal cholesterol absorption with plant sterol consumption is a well-characterized strategy to lower LDL-C and potentially reduce cardiovascular disease risk. However, over 50 years of clinical research demonstrate that there is significant heterogeneity in the individual LDL-C lowering response to plant sterol therapy. A clear understanding of why plant sterols work effectively in some individuals but not in others will ensure optimal integration of plant sterols in future personalized nutritional lipid-lowering strategies. This review will examine the current knowledge base surrounding the metabolic and genetic determinants of LDL-C lowering in response to plant sterol consumption.
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