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Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical, chemical, and...
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...

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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Epidermal barrier function and systemic diseases.

Marcia Ramos-e-Silva1, Claudio de-Moura-Castro Jacques

  • 1Sector of Dermatology and Post-Graduation Course, HUCFF-UFRJ, and School of Medicine, Universidade Federal do Rio de Janeiro, Rua Dona Mariana 149/401, Rio de Janeiro 22471-210, Brazil. ramos.e.silva@dermato.med.br

Clinics in Dermatology
|April 18, 2012
PubMed
Summary
This summary is machine-generated.

The skin

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Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
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Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

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Last Updated: May 23, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
10:51

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

Area of Science:

  • Dermatology and immunology.
  • Skin barrier function research.

Background:

  • The skin's epidermis acts as a crucial protective barrier against environmental insults.
  • The stratum corneum and its lipid matrix are key components of the skin barrier.
  • Epidermal barrier dysfunction is implicated in skin diseases like atopic dermatitis and psoriasis.

Purpose of the Study:

  • To review the impact of systemic diseases on skin homeostasis.
  • To explore the relationship between systemic conditions and epidermal barrier function.

Main Methods:

  • Literature review of systemic diseases affecting skin homeostasis.
  • Analysis of the role of epidermal barrier in disease pathogenesis.

Main Results:

  • Epidermal barrier integrity is essential for preventing dehydration and environmental damage.
  • Dysfunction in the skin barrier is a significant factor in the development of skin diseases.
  • Systemic diseases can influence and be influenced by compromised skin barrier function.

Conclusions:

  • Maintaining skin homeostasis is vital for overall health.
  • Understanding the interplay between systemic diseases and skin barrier function is crucial for effective treatment.
  • Further research is needed to elucidate the complex interactions.