Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eponyms and clinical entities from the land of Israel.

Clinics in dermatology·2023
Same author

The Granulated Sweetener Packet Sign.

Acta dermatovenerologica Croatica : ADC·2023
Same author

The Conundrum of Toys and Hobbies: Nitendo.

Skinmed·2021
Same author

The Conundrum of Toys and Hobbies: A Skateboard Story.

Skinmed·2021
Same author

The rash from nuisance to life threatening: Part II.

Clinics in dermatology·2020
Same author

The life-threatening rash of poisoning.

Clinics in dermatology·2019
Same journal

Letter to the editor in reply to "Ethics of Rising Trends in Dermatology Publications Using Large-Scale Databases".

Clinics in dermatology·2026
Same journal

Ethics of suggesting image-guided superficial radiation therapy on the pathology report.

Clinics in dermatology·2026
Same journal

Tanorexia: The Psychodermatology of Compulsive Tanning.

Clinics in dermatology·2026
Same journal

Ear manifestations of connective tissue diseases: A dermatologic, histopathologic, and clinicopathologic review.

Clinics in dermatology·2026
Same journal

Discovery of an intravenous drug injection site: A meticulous cutaneous examination provides the forensic dermatologic clue to a diagnosis of homicide.

Clinics in dermatology·2026
Same journal

Sherlock Holmes and the mystery of the deadly diet.

Clinics in dermatology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

Psychological stress and epidermal barrier function.

Edith Orion1, Ronni Wolf

  • 1Psychodermatology Clinic, Kaplan Medical Center, Rehovot 76100, Israel. eorion@013.net

Clinics in Dermatology
|April 18, 2012
PubMed
Summary
This summary is machine-generated.

Psychological stress impacts skin health by affecting the epidermal barrier. Understanding this mind-skin connection is crucial for managing skin diseases exacerbated by stress.

More Related Videos

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
10:51

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

Related Experiment Videos

Last Updated: May 23, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
10:51

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Published on: July 14, 2017

Area of Science:

  • Dermatology
  • Psychoneuroimmunology
  • Skin Barrier Function

Background:

  • The skin serves as a critical barrier against external and internal stimuli.
  • Psychological stress is increasingly recognized for its physiological impact.
  • The mind-body connection is a well-established pathway for communication between the brain and body.

Purpose of the Study:

  • To explore the vulnerability of the skin's epidermal barrier to psychological stress.
  • To understand the physiological mechanisms linking stress and skin health.
  • To investigate how stress influences the development and exacerbation of skin diseases.

Main Methods:

  • Review of current literature on stress, skin physiology, and dermatology.
  • Analysis of psychoneuroimmunological pathways.
  • Examination of epidermal barrier function under stress conditions.

Main Results:

  • Psychological stress can disrupt epidermal barrier integrity.
  • The mind-skin axis plays a significant role in dermatological conditions.
  • Stress is implicated in the initiation, maintenance, and worsening of various skin diseases.

Conclusions:

  • The epidermal barrier's susceptibility to psychological stress is a key factor in skin disease pathogenesis.
  • Further research into the mind-skin connection is essential for dermatological advancements.
  • Targeting stress-related pathways may offer novel therapeutic strategies for skin conditions.