Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The expertise effect: how advancing skills in frozen elephant trunk have broadened surgical indication for acute dissection.

The Journal of cardiovascular surgery·2026
Same author

Comparison of a novel mechanical valve versus stented bioprosthetic valves for isolated mitral valve replacement in patients older than 65 years.

JTCVS open·2025
Same author

Mechanisms of cellular and molecular responses in Mytilus galloprovincialis exposed to human pharmaceuticals ibuprofen, paroxetine and their mixture.

Environmental research·2025
Same author

Mitral Annular Calcification: The "Pack and Seal" Technique.

Heart, lung & circulation·2025
Same author

Hop leaves: From waste to a valuable source of bioactive compounds - A multidisciplinary approach to investigating potential applications.

Heliyon·2024
Same author

Positive Impacts of Aphanizomenon Flos Aquae Extract on Obesity-Related Dysmetabolism in Mice with Diet-Induced Obesity.

Cells·2023

Related Experiment Video

Updated: May 23, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
06:52

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

Simple model systems: a challenge for Alzheimer's disease.

Marta Di Carlo1

  • 1Istituto di Biomedicina ed Immunologia Molecolare (IBIM) Alberto Monroy CNR, via Ugo La Malfa 153, 90146 Palermo, Italy. di-carlo@ibim.cnr.it.

Immunity & Ageing : I & A
|April 18, 2012
PubMed
Summary

Simple animal models like worms and flies are crucial for understanding Alzheimer's disease (AD) mechanisms and testing new treatments, advancing neurodegenerative disease research.

Area of Science:

  • Biomedical Research
  • Neuroscience
  • Genetics

Background:

  • Biomedical advances increased life expectancy but also led to a rise in age-related neurodegenerative diseases like Alzheimer's disease (AD).
  • Neurodegenerative disorders are complex, late-onset conditions characterized by memory loss, cognitive deficits, and motor dysfunction.

Purpose of the Study:

  • To highlight the utility of simple animal models in understanding Alzheimer's disease.
  • To demonstrate how these models aid in identifying AD-associated genes and proteins.
  • To showcase their role in evaluating potential therapeutic interventions for AD.

Main Methods:

  • Utilizing simple animal models including worms, fishes, flies, Ascidians, and sea urchins.
  • Leveraging the discovery of specific genes and proteins linked to Alzheimer's disease.

More Related Videos

A Caenorhabditis elegans Model System for Amylopathy Study
10:33

A Caenorhabditis elegans Model System for Amylopathy Study

Published on: May 17, 2013

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
10:02

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Published on: May 28, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
06:52

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

A Caenorhabditis elegans Model System for Amylopathy Study
10:33

A Caenorhabditis elegans Model System for Amylopathy Study

Published on: May 17, 2013

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
10:02

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Published on: May 28, 2017

  • Employing advanced technologies for the creation of transgenic animal models.

    • Main Results:

    • Simple animal models have facilitated the elucidation of biochemical mechanisms underlying Alzheimer's disease.
    • These models have been instrumental in overcoming the scarcity of natural AD models.
    • Key information for therapeutic intervention evaluation has been obtained using these systems.

    Conclusions:

    • Simple animal models are invaluable tools in Alzheimer's disease research.
    • They accelerate the understanding of disease pathology and the development of effective treatments.
    • Continued use of these models is essential for advancing neuroprotection strategies.