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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Lymphomas and leukemias due to infectious organisms
1City of Hope National Medical Center, Duarte, CA, USA. alevine@coh.org
Hematology (Amsterdam, Netherlands)
|April 18, 2012
Summary
Infectious organisms cause about 25% of human cancers globally. This review details the role of Human T lymphotrophic virus type I, Hepatitis C virus, and Helicobacter pylori in hematologic malignancies.
Area of Science:
- Oncology
- Infectious Diseases
- Hematology
Background:
- Approximately 25% of human malignancies worldwide are linked to infectious organisms.
- Infectious agents contribute to roughly 10% of cancers in developed nations.
- While immunodeficiency can increase risk, most patients diagnosed with infection-associated cancers are not immunocompromised.
Purpose of the Study:
- To review the role of specific infectious agents in hematologic malignancies.
- To describe the pathogenesis, clinical presentation, and treatment of associated cancers.
- To focus on Human T lymphotrophic virus type I, Hepatitis C virus, and Helicobacter pylori.
Main Methods:
- Review of literature on infectious agents and hematologic malignancies.
- Focus on Human T lymphotrophic virus type I (HTLV-1) and Adult T cell leukemia/lymphoma (ATLL).
- Focus on Hepatitis C virus (HCV) and associated lymphomas.
- Focus on Helicobacter pylori and gastric MALT lymphoma.
Main Results:
- HTLV-1 is associated with Adult T cell leukemia/lymphoma (ATLL).
- Hepatitis C virus (HCV) is linked to splenic marginal zone lymphoma and other lymphomas.
- Helicobacter pylori is associated with gastric MALT lymphoma.
- Human Herpesvirus 8 (HHV8/KSHV) is linked to primary effusion lymphoma, multicentric Castleman disease, and Kaposi's sarcoma.
- Epstein Barr Virus (EBV) is associated with Burkitt lymphoma and nasal T-cell lymphoma.
Conclusions:
- Infectious agents play a significant role in the etiology of various hematologic malignancies.
- Understanding the pathogenesis, clinical features, and therapeutic strategies for these infections is crucial.
- Further research into the mechanisms and treatments for infection-driven cancers is warranted.
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