Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')<sub>2</sub>-Modified Graphene Field-Effect Biosensor.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia.

American journal of speech-language pathology·2026
Same author

CKS2 is overexpressed in high-grade and recurrent meningiomas and functions as an oncogene via the CKS2/miR-26a/miR-101 axis.

Computers in biology and medicine·2025
Same author

Early White Matter Microstructure Alterations in Infants with Down Syndrome.

NeuroImage·2025
Same author

Palonosetron versus tropisetron with dexamethasone for prevention of postoperative nausea and vomiting in pediatric adenotonsillectomy: a single center, randomized controlled trial.

Frontiers in medicine·2025
Same author

Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.

Journal of neurodevelopmental disorders·2025

Related Experiment Video

Updated: May 23, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Quantitative tract-based white matter development from birth to age 2years.

Xiujuan Geng1, Sylvain Gouttard, Anuja Sharma

  • 1Department of Psychiatry, 229 Medical School Wing B, University of North Carolina, School of Medicine, Chapel Hill, NC 27514, USA. xiujuan_geng@med.unc.edu

Neuroimage
|April 19, 2012
PubMed
Summary

Human brain white matter grows rapidly in the first two years of life. This study reveals detailed white matter maturation patterns in major fiber tracts using advanced diffusion imaging techniques.

More Related Videos

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: May 23, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Limited large-scale studies exist on normal human brain white matter development in early childhood.
  • Understanding white matter maturation is crucial for identifying developmental abnormalities.

Purpose of the Study:

  • To characterize white matter maturation patterns in major fiber pathways in healthy children from birth to age two.
  • To investigate developmental changes using diffusion parameters like fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD).

Main Methods:

  • Utilized diffusion tensor imaging (DTI) data from a large cohort of healthy children (birth to 2 years).
  • Employed tract-based analysis on ten major fiber pathways (commissural, association, projection tracts).
  • Transformed DTI data to a population-specific atlas using longitudinal large deformation diffeomorphic registration.

Main Results:

  • All examined fiber bundles demonstrated increasing FA and decreasing RD and AD during the first two years.
  • Maturation rates were faster in the first year compared to the second year for all tracts.
  • RD and FA showed greater percentage changes than AD, with minimal gender effects observed.

Conclusions:

  • The study confirms general rules of white matter maturation, with distinct temporal and spatial patterns.
  • Tract-based analysis provides more detailed developmental insights than traditional ROI-based methods.
  • This framework offers a promising approach for studying localized white matter maturation patterns in fiber tracts.