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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study

Atsuhiro Kanno1, Masahiro Kikuya, Takayoshi Ohkubo

  • 1Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and PharmaceuticalSciences, Sendai, Japan.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|April 19, 2012
PubMed

Insights

Pre-hypertension significantly increases the risk of developing chronic kidney disease (CKD). This condition is a considerable cause of CKD in the general population, highlighting the importance of early blood pressure management.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Hypertension is a known risk factor for chronic kidney disease (CKD).
  • The association between pre-hypertension and CKD incidence remains unclear.
  • Investigating pre-hypertension's role in CKD is crucial for public health strategies.

Purpose of the Study:

  • To determine if pre-hypertension is associated with an increased risk of developing CKD.
  • To quantify the risk of CKD in individuals with pre-hypertension compared to normotensive individuals.
  • To assess the population-attributable fraction of CKD due to pre-hypertension.

Main Methods:

  • A cohort study of 2150 Japanese individuals without pre-existing CKD.
  • CKD incidence defined by proteinuria or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m(2).
  • Cox regression analysis adjusted for multiple risk factors, categorizing participants per JNC 7 guidelines.

Main Results:

  • Over 6.5 years, 461 CKD incidences were recorded.
  • Pre-hypertension (HR 1.49) and hypertension stages 1 (HR 1.83) and 2 (HR 2.55) were significantly associated with increased CKD risk.
  • The population-attributable fraction for pre-hypertension was comparable to hypertension stages.

Conclusions:

  • Pre-hypertension is significantly associated with an increased risk of CKD.
  • Pre-hypertension is a considerable cause of CKD in the general population.
  • Early detection and management of pre-hypertension may help prevent CKD.
Abstract

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