Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Patient-oriented simulation based on Monte Carlo algorithm by using MRI data.

Ching-Cheng Chuang1, Yu-Tzu Lee, Chung-Ming Chen

  • 1Institute of Biomedical Engineering and National Taiwan University Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, Republic of China.

Biomedical Engineering Online
|April 19, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.

Biomedical optics express·2026
Same author

Subclinical immunometabolic perturbations in the neonatal lung following maternal microplastic exposure in mice.

Toxicology·2026
Same author

A multi-task masked autoencoder with GAN-based augmentation for PD-L1 prediction from chest CT images.

Scientific reports·2026
Same author

Hippo signaling pathway regulates branching morphogenesis of the fetal lung under hypoxia.

Pediatric research·2026
Same author

Functional near-infrared spectroscopy identifies neural biomarkers of burnout in active-duty Police officers.

Scientific reports·2026
Same author

ASO Visual Abstract: CT-Based Prediction of Visceral Pleural Invasion in Lung Adenocarcinoma ≤ 3 cm: Enhancing Deep Learning Specificity by Waiving Chest Wall Information.

Annals of surgical oncology·2026

This study introduces a patient-specific brain model using MRI and Monte Carlo simulations for optimizing near-infrared spectroscopy (NIRS) calibration. The approach aids in designing personalized NIRS systems and offers insights into brain structure.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Computational Neuroscience

Background:

  • Monte Carlo simulations of light propagation in MRI-based head models are common.
  • Patient-specific simulations for individualized calibration in near-infrared spectroscopy (NIRS) are lacking.
  • This study presents a novel approach for brain modeling using MRI segmentation for NIRS calibration.

Purpose of the Study:

  • To develop an individualized brain model for NIRS calibration using in vivo MRI T1 3D images.
  • To investigate the application of Monte Carlo simulations for personalized NIRS system design.
  • To explore the potential of optical methods for both functional and structural brain information.

Main Methods:

  • An individualized five-layer brain model was created from a 3D in vivo MRI scan.

More Related Videos

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
13:20

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

Related Experiment Videos

Last Updated: May 23, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
13:20

Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance

Published on: December 5, 2025

  • A three-dimensional time-resolved Monte Carlo algorithm simulated photon migration.
  • Photon paths were traced for various source-detector separations to characterize brain structures.

    • Main Results:

    • Patient-oriented simulations identified optimal source-detector separations (~3.3 cm) for individualized NIRS design.
    • Cerebral cortex folding caused significant distortions in light propagation.
    • Expanded cerebrospinal fluid (CSF) layers indicated deeper spatial sensitivity profiles, suggesting potential for detecting brain atrophy.

    Conclusions:

    • The developed 3D time-resolved brain modeling method accurately represents the human brain.
    • This approach provides valuable information for systematic NIRS design and calibration in individualized cases using prior MRI data.