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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules
Do Hyun Kang1, Ho-Sup Jung, Namyoung Ahn
1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742, Korea.
Chemical Communications (Cambridge, England)
|April 19, 2012
Abstract:
We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP(2)) phospholipids. The developed PDA-PIP(2) sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
