Related Experiment Video
Updated: May 23, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
[Application research of hot-melt extrusion in preparation of solid dispersion]
Mei-Wan Chen1, Wen-Rong Chen, Tong-Kai Chen
1The State key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
Abstract:
Hot-melt extrusion (HME) is mainly used to enhance the dissolution rate and bioavailability of poorly water soluble drugs. It has many advantages, such as simple process, continuous operation, high efficiency, on-line monitoring and so on. HME provides an innovative approach, which has been concerned by pharmaceutical workers, for preparation of solid dispersion abroad. This article reviews recent advances on preparation of solid dispersion by HME in preparation processing, carrier materials and quality evaluation in order to further promote and apply HME in preparation of solid dispersion.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Alternative Methods
Bioavailability Enhancement: Drug Solubility Enhancement
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

