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Updated: May 23, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Potential avenues for immunotherapy of colitis-associated neoplasia
Maximilian J Waldner1, Markus F Neurath
1Department of Medicine 1, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany.
Abstract:
In patients with inflammatory bowel disease, chronic intestinal inflammation severely increases the risk for cancer development. In fact, various aspects of inflammation such as oxidative stress, cyclooxygenases and proinflammatory cytokines have been shown to support many aspects of cancer growth. During recent years, various experimental studies have increased our understanding of the molecular mechanisms leading to colitis-associated cancer. In particular, cytokines such as TNF-α or IL-6, which are involved in the pathogenesis of inflammation and cancer development, could be promising targets for the molecular prevention of colitis-associated cancer.
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