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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Concise total synthesis of (-)-mersicarpine.

Yusuke Iwama1, Kentaro Okano, Kenji Sugimoto

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.

Organic Letters
|April 20, 2012
PubMed
Summary

A concise total synthesis of (-)-mersicarpine was achieved from a readily available cyclohexanone precursor. The key azepinoindole core was efficiently constructed using a DIBAL-H-mediated reductive ring-expansion of an oxime.

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