Related Experiment Video
Updated: May 23, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
Terahertz interferometric synthetic aperture tomography for confocal imaging systems
M S Heimbeck1, D L Marks, D Brady
1Charles M. Bowden Research Center, Army Aviation & Missile RD&E Center, Redstone Arsenal, Alabama 35898, USA. martin.heimbeck@us.army.mil
Terahertz interferometric synthetic aperture tomography (TISAT) enables high-resolution confocal imaging of extended objects. This technique significantly enhances imaging depth beyond the instrument's focus limitations.
Area of Science:
- Optics and Photonics
- Imaging Science
- Terahertz Technology
Background:
- Confocal imaging typically has a limited depth of focus.
- Extended objects pose challenges for high-resolution imaging techniques.
- Terahertz (THz) imaging offers unique material penetration capabilities.
Purpose of the Study:
- To demonstrate Terahertz (THz) interferometric synthetic aperture tomography (TISAT) for confocal imaging within extended objects.
- To adapt existing algorithms for THz imaging challenges.
- To achieve diffraction-limited resolution over an extended depth range.
Main Methods:
- Combined attributes of synthetic aperture radar and optical coherence tomography.
- Adapted interferometric synthetic aperture microscopy algorithms.
- Developed a frequency-swept two-dimensional TISAT confocal imaging instrument.
Main Results:
- Successfully demonstrated TISAT for confocal imaging of extended objects.
- Accounted for diffraction and defocusing effects on THz beam width.
- Achieved in-focus, diffraction-limited resolution over a depth 12 times larger than the instrument's depth of focus.
Conclusions:
- TISAT is a viable technique for extending the imaging depth in confocal THz imaging.
- The developed method can be readily extended to three dimensions and greater depths.
- This advancement has implications for non-destructive testing and material characterization.
More Related Videos
Related Concept Videos
Confocal Fluorescence Microscopy
Total Internal Reflection Fluorescence Microscopy
Electron Microscope Tomography and Single-particle Reconstruction
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

