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Updated: May 23, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Severe asthma: future treatments.
P M O'Byrne1, N Naji, G M Gauvreau
1Firestone Institute for Respiratory Health, St. Joseph's Hospital and Department of Medicine, McMaster University, Hamilton, Ontario, Canada. obyrnep@mcmaster.ca
Summary
New treatments for severe refractory asthma target specific inflammation. Monoclonal antibodies against IL-5 and other biologics show promise in improving lung function and reducing exacerbations for better asthma control.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Severe refractory asthma remains uncontrolled despite high-dose inhaled corticosteroids (ICS) and long-acting beta-agonists (LABAs).
- Significant unmet needs exist for improving asthma control and reducing exacerbation risk in these patients.
Purpose of the Study:
- To review promising new treatment approaches for severe refractory asthma.
- To highlight therapies targeting specific inflammatory pathways and cells.
Main Methods:
- Review of current and emerging treatments for severe refractory asthma.
- Analysis of studies on monoclonal antibodies, bronchial thermoplasty, and small molecule antagonists.
Main Results:
- Monoclonal antibodies targeting IL-5 improve lung function, asthma control, and reduce exacerbations, allowing for corticosteroid reduction.
- Bronchial thermoplasty may benefit selected patients by improving control and reducing exacerbations.
- Emerging therapies include CXCR2 and CRTh2 antagonists, and antibodies against IL-4/IL-13, with inhaled anti-sense also showing potential.
Conclusions:
- Several novel treatment options are under investigation for severe refractory asthma.
- These include biologics targeting inflammatory mediators, procedural interventions, and small molecule drugs.
- Patient phenotyping is crucial for selecting individuals likely to benefit from these targeted therapies.
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