Related Experiment Video
Updated: May 23, 2026

RNA-Associated Chromatin DNA-DNA Interaction Method
Published on: April 30, 2026
Dynamics in multi-domain protein recognition of RNA
Cameron D Mackereth1, Michael Sattler
1Institut Européen de Chimie et Biologie, Inserm U869 and Univ. Bordeaux, 2 rue Robert Escarpit, 33607 Pessac, France. c.mackereth@iecb.u-bordeaux.fr
Abstract:
Protein-RNA interactions play essential roles in gene regulation and RNA metabolism. While high-resolution structures have revealed principles of RNA recognition by individual RNA binding domains (RBDs), the presence of multiple RBDs in many eukaryotic proteins suggests additional modes of RNA recognition by combination and cooperation of these interactions. Recent structures, together with biochemical and biophysical studies have revealed novel principles of RNA recognition by multi-domain proteins. These examples highlight an important role for dynamics in RNA recognition, with mechanisms including fly-casting and conformational selection, and advocate the use of solution techniques for their analysis.
Related Concept Videos
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Bacterial RNA Polymerase
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
RNA Stability
RNA Stability
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...

