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Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Published on: July 19, 2024
Calming down T cell acute leukemia
Emilio Hirsch1, Roberto Chiarle
1Molecular Biotechnology Center, University of Torino, Torino, Italy. emilio.hirsch@unito.it
Cancer Cell
|April 21, 2012
Abstract:
Signaling from class I phosphoinositide 3-kinase (PI3K) is often deregulated in leukemia and lymphoma, but which isoforms are involved in T cell acute lymphoblastic leukemia (T-ALL) was not known. In this issue of Cancer Cell, Subramaniam et al. show that T-ALL can be tamed by inhibiting γ and δ PI3K isoforms.

