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Hijacking T cell differentiation: new insights in TLX function in T-ALL
Bryan King1, Panagiotis Ntziachristos, Iannis Aifantis
1Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
Abstract:
TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.
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