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Hijacking T cell differentiation: new insights in TLX function in T-ALL

Bryan King1, Panagiotis Ntziachristos, Iannis Aifantis

  • 1Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.

Cancer Cell
|April 21, 2012
PubMed
Summary

Homeobox genes TLX1 and TLX3 are implicated in T-cell acute lymphoblastic leukemia (T-ALL). New research shows ETS-1 recruits these factors to repress T-cell differentiation.

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