Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutathione conjugate mediated toxicities.

T J Monks1, M W Anders, W Dekant

  • 1Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin 78712.

Toxicology and Applied Pharmacology
|October 1, 1990
PubMed
Summary

Glutathione (GSH) conjugation, once seen as protective, can activate xenobiotics into toxic metabolites. This research explores GSH-mediated bioactivation pathways and their toxicological significance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moonlighting in drug metabolism.

Drug metabolism reviews·2020
Same author

The mercapturic acid pathway.

Critical reviews in toxicology·2020
Same author

Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity.

The pharmacogenomics journal·2017
Same author

Diacetyl and related flavorant α-Diketones: Biotransformation, cellular interactions, and respiratory-tract toxicity.

Toxicology·2017
Same author

Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.

Molecular pharmacology·2016
Same author

Do flow volume loops alter surgical management in patients with a goitre?

Clinical endocrinology·2014

Area of Science:

  • Toxicology
  • Biochemistry
  • Cellular Biology

Background:

  • Glutathione (gamma-glutamyl-L-cysteinylglycine: GSH) is a key cellular antioxidant and detoxifying agent.
  • Traditionally, GSH conjugation neutralizes xenobiotics, aiding their excretion as mercapturic acids.
  • Emerging evidence highlights GSH's role in bioactivating chemicals into toxic metabolites.

Purpose of the Study:

  • To discuss recent findings on glutathione conjugate-mediated toxicities.
  • To explore mechanisms and modulation of GSH conjugate-dependent toxic effects.
  • To establish a consensus on the significance of this research and identify future directions.

Main Methods:

  • Review of presentations from the 1990 Society of Toxicology Annual Meeting symposium.

Related Experiment Videos

  • Identification and categorization of four distinct GSH-dependent bioactivation pathways.
  • Analysis of toxicological implications of these bioactivation mechanisms.

    • Main Results:

    • Four types of GSH-dependent xenobiotic bioactivation reactions were identified.
    • These include formation of sulfur mustards, cysteine conjugate beta-lyase activation, transport/targeting roles, and release of toxic agents.
    • GSH conjugation can lead to cytotoxic, genotoxic, and mutagenic metabolites.

    Conclusions:

    • GSH conjugation is a critical pathway in the bioactivation of various xenobiotics.
    • Understanding these pathways is crucial for assessing chemical toxicity.
    • Further research is needed to fully elucidate the mechanisms and implications of GSH conjugate-mediated toxicities.