[Metabolic syndrome and urinary disorders]
G Amarenco1, A Serikoff, E Chartier-Kastler
1GREEN Groupe de recherche clinique en neuro-urologie, GRC UPMC, université Pierre-et-Marie-Curie, service de neuro-urologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France. gerard.amarenco@tnn.aphp.fr
Summary
Metabolic syndrome (MetS) is strongly linked to overactive bladder. Common causes include autonomic nervous system alterations and hyperglycemia affecting bladder nerves.
Area of Science:
- Urology
- Endocrinology
- Metabolic Disorders
Background:
- Metabolic syndrome (MetS) is a cluster of conditions including central obesity, high blood pressure, high triglycerides, low HDL cholesterol, and insulin resistance.
- Overactive bladder (OAB) is characterized by urinary urgency, often with frequency and nocturia.
Purpose of the Study:
- To review and discuss the links between metabolic syndrome and bladder dysfunction, specifically overactive bladder syndrome.
- To explore potential pathophysiological mechanisms connecting MetS and OAB.
Main Methods:
- A comprehensive literature search of PubMed/Medline was performed.
- Keywords included "metabolic syndrome" and "bladder" (or "incontinence" or "overactive bladder").
- All paper types were analyzed without date or language restrictions (117 papers).
Main Results:
- A strong correlation exists between MetS and overactive bladder.
- Sustained hyperglycemia may impact parasympathetic neurons in the pelvic ganglion, contributing to storage symptoms.
- Autonomic nervous system alterations are hypothesized as a link between MetS and OAB.
Conclusions:
- Frequent links exist between MetS and urinary disorders.
- Common pathophysiological factors, particularly autonomic nervous system alterations, are observed.
- Further research into the MetS-OAB connection is warranted.
Related Concept Videos
01:20Disorders of the Urinary System
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
01:21Nursing Assessment of the Genitourinary System I: Health History
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
01:24Physiology of Urine Formation
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
01:29Urine Studies I: Urinalysis
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...