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Related Experiment Video

Updated: May 23, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

An integrated platform for image-guided cardiac resynchronization therapy.

Ying Liang Ma¹, Anoop K Shetty, Simon Duckett

¹Division of Imaging Sciences and Biomedical Engineering, King's College London SE1 7EH, UK. y.ma@kcl.ac.uk

Physics in Medicine and Biology

|April 21, 2012

Summary

This summary is machine-generated.

Optimizing cardiac resynchronization therapy (CRT) lead placement using cardiac MRI data and a novel navigation system improved accuracy. This approach aims to enhance CRT effectiveness for heart failure patients who do not initially respond to treatment.

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Area of Science:

Cardiovascular Imaging and Interventions
Medical Device Navigation Systems

Background:

Cardiac resynchronization therapy (CRT) is a treatment for heart failure, but a significant portion of patients (30%) do not respond.
Suboptimal placement of the left ventricular (LV) lead is a primary reason for CRT non-response.
Integrating cardiac anatomy, scar, and dyssynchrony information from cardiac magnetic resonance imaging (MRI) may guide optimal LV lead positioning.

Purpose of the Study:

To develop and validate a platform for guiding CRT lead placement using pre-procedural MRI data integrated with live x-ray fluoroscopy.
To assess the accuracy of a novel 3D to 2D navigation technique, 'Cardiac Unfold', for intuitive LV lead targeting.

Main Methods:

A complete platform was developed, combining pre-procedural cardiac MRI (anatomical models, motion, scar imaging) with live x-ray fluoroscopy.
MRI-derived cardiac models were registered to fluoroscopy using catheter views, with registration maintained via C-arm tracking and motion compensation.
A novel 'Cardiac Unfold' technique was developed to display 3D cardiac data in an unfolded 2D format for real-time navigation.

Main Results:

The 3D roadmap to 2D x-ray image registration achieved a 2D error of 1.2 ± 0.7 mm.
The 'Cardiac Unfold' navigation technique demonstrated an LV pacing lead electrode registration error of 2.2 ± 0.9 mm.
The platform and 'Cardiac Unfold' navigation were successfully demonstrated in 21 patients and four real-time clinical cases.

Conclusions:

A novel platform integrating pre-procedural MRI with live fluoroscopy can guide optimal LV lead placement for CRT.
The 'Cardiac Unfold' navigation technique offers intuitive and accurate guidance for CRT procedures.
This approach has the potential to improve CRT response rates by ensuring precise lead positioning.