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Updated: Oct 2, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
Histone deletion mutants challenge the molecular clock hypothesis
1Department of Chemistry, Lehigh University, Bethlehem, PA 18015.
Abstract:
A basic tenet of the molecular clock hypothesis is that the rate of sequence drift for a protein depends on the number of amino acid residues that are critical for its function. However, recent experiments have determined that, although core histone sequences are highly conserved among eukaryotes, large regions of the proteins are dispensable for growth in yeast.
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