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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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[Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors]

Masaki Ieda1

  • 1Department of Clinical and Molecular Cardiovascular Research, Department of Cardiology, Keio University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 24, 2012
PubMed
Abstract

No abstract available in PubMed .

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...