Related Experiment Video
Updated: May 23, 2026
09:05
MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
[Roles of COPI related proteins during virus replication]
Guang-Bo Yang1, Lei-Liang Zhang
1Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China.
Bing Du Xue Bao = Chinese Journal of Virology
|April 24, 2012
Summary
COPI protein complexes are essential for vesicle transport. Viruses exploit COPI proteins like coatomer, ARF1, and GBF1 to aid their replication, a key area in virology research.
Area of Science:
- Cell Biology
- Virology
- Molecular Biology
Context:
- The COPI (coatomer protein I) complex facilitates retrograde vesicle transport from the Golgi apparatus to the endoplasmic reticulum.
- Viral replication strategies often involve the manipulation of host cell machinery.
Purpose:
- To review the current understanding of how COPI-related proteins are utilized by various viruses during their replication cycles.
Summary:
- Viruses, including RNA, DNA, and retroviruses, frequently hijack host cell factors.
- Specific COPI-related proteins, such as coatomer, ARF1, and GBF1, are commonly adapted by viruses.
- This adaptation aids in critical steps of viral replication, highlighting a conserved viral strategy.
Impact:
- Understanding these viral-host interactions can reveal novel therapeutic targets for antiviral interventions.
- This knowledge deepens our comprehension of fundamental cellular processes and viral pathogenesis.
Related Concept Videos
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:20Viral Replication: Lytic Cycle
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
00:59COP Coated Vesicles
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
02:36RNA Polymerase II Accessory Proteins
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
02:36RNA Polymerase II Accessory Proteins
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...