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Related Experiment Videos

Periorbital necrotizing fasciitis -- a review.

Shantha Amrith1, Vijaya Hosdurga Pai, Wong Wan Ling

  • 1Department of Ophthalmology, National University Health System, Singapore City, SingaporeDepartment of Ophthalmology, Kasturba Medical College, Manipal University, Manipal, IndiaSingapore Eye Research Institute, Singapore National Eye Center, Singapore City, Singapore.

Acta Ophthalmologica
|April 24, 2012
PubMed
Summary

Periorbital necrotizing fasciitis (NF) is a rare but severe infection. Early recognition and treatment are crucial to prevent death, particularly from toxic shock syndrome, with mortality rates appearing to decline.

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Area of Science:

  • Infectious Diseases
  • Ophthalmology
  • Plastic Surgery

Background:

  • Necrotizing fasciitis (NF) is a severe, rapidly progressing infection affecting superficial fascia and overlying skin.
  • Periorbital NF, though uncommon due to the area's rich blood supply, can be fatal.
  • This study reviews factors associated with mortality in periorbital NF.

Purpose of the Study:

  • To systematically review and analyze factors linked to death in periorbital NF.
  • To identify predisposing conditions, triggers, causative organisms, and the role of toxic shock.
  • To assess the significance of risk factors contributing to mortality.

Main Methods:

  • Systematic literature review of English-language periorbital NF cases over 20 years.
  • Analysis of 94 patients from 61 reports, examining clinical data and outcomes.
Keywords:
fasciitismortalitynecrotisingperiorbital infectionstoxic shock syndrome

Related Experiment Videos

  • Statistical analysis to determine factors significantly associated with mortality.

    • Main Results:

    • Group A beta-hemolytic Streptococcus was the most common organism (51.1%).
    • Toxic shock syndrome (30.9%) and vision loss (13.8%) were significant complications.
    • Mortality was 8.5%, with toxic shock, type 1 infections, facial involvement, and blindness significantly associated with death.

    Conclusions:

    • Mortality from periorbital NF appears to be decreasing.
    • Early diagnosis and prompt treatment are vital to prevent fatal outcomes, especially toxic shock.
    • Type 1 infections, though rare, pose a significant mortality risk in the periorbital region.