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Ophthalmic involvement in nasopharyngeal carcinoma
Wendy Meihua Wong1, Stephanie Ming Young1, Shantha Amrith1
1a Department of Ophthalmology , National University Health System , Singapore , Singapore.
Orbit (Amsterdam, Netherlands)
|April 8, 2017
Summary
Ophthalmic involvement affects 7.6% of nasopharyngeal carcinoma (NPC) patients, often presenting as orbital invasion. Early recognition of these eye symptoms is crucial for better outcomes in NPC patients.
Area of Science:
- Ophthalmology
- Oncology
- Head and Neck Surgery
Background:
- Nasopharyngeal carcinoma (NPC) can present with or develop ophthalmic complications.
- Understanding the spectrum of ocular involvement is vital for diagnosis and management.
Purpose of the Study:
- To describe the ophthalmic involvement in patients with nasopharyngeal carcinoma (NPC) before and after treatment.
- To analyze the types and frequencies of ocular complications associated with NPC.
Main Methods:
- Retrospective review of data from 354 consecutive NPC patients treated at a single tertiary center (April 2007 - July 2015).
- Identification and categorization of patients with ophthalmic involvement due to NPC or its treatment.
Main Results:
- Ophthalmic involvement was identified in 27 (7.6%) patients.
- Symptomatic orbital invasion occurred in 13 patients (48.1%), with a mean age of 54; 8 had no prior NPC diagnosis.
- Other findings included ocular signs without invasion (29.6%), incidental orbital involvement (7.4%), and radiotherapy complications (14.8%).
Conclusions:
- Ophthalmic symptoms, particularly from orbital invasion, can be the initial presentation of NPC.
- NPC with ophthalmic involvement may affect a younger demographic, underscoring the importance of early recognition to reduce morbidity and mortality.