[Secondary gliosarcoma: case report]
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Updated: May 23, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
Rajae Tahri1, Omar Boulahroud, Khadija Setti
1Service d'anatomie pathologique, hôpital militaire d'instruction Mohammed V de Rabat, Rabat, Maroc. rajae.tahri@gmail.com
Abstract:
Gliosarcoma is a rare tumor of the central nervous system, consisting of gliomatous and sarcomatous elements. The glioblastoma can undergo a change in phenotype, transforming into a gliosarcoma, especially when the tumor has been treated with radiotherapy. Features unique to gliosarcoma compared to glioblastoma include their potential to appear similar to a meningioma at macroscopy, repeated reports of metastases and infrequency of EGFR mutations. We present a case of secondary gliosarcoma to emphasize on the specificities, essentially diagnostical of this rare entity.

