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Platelet function after intramuscular diclofenac.

I Power1, W A Chambers, I A Greer

  • 1University Department of Anaesthetics, Royal Infirmary, Edinburgh.

Anaesthesia
|November 1, 1990
PubMed
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Diclofenac administration was found to prolong skin bleeding time and reduce platelet aggregation in patients undergoing thoracotomy. This non-steroidal anti-inflammatory drug impacts hemostasis and platelet function.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Hematology

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management.
  • Understanding the impact of NSAIDs like diclofenac on hemostasis is crucial, especially in surgical patients.

Purpose of the Study:

  • To investigate the effects of diclofenac on skin bleeding time.
  • To assess the impact of diclofenac on in vitro whole blood platelet aggregation.

Main Methods:

  • A randomized, double-blind, controlled study design was employed.
  • Twenty thoracotomy patients were divided into two groups: one receiving diclofenac 75 mg intramuscularly, and a control group.
  • Skin bleeding times and platelet aggregation tests were conducted pre- and post-anesthesia induction.

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Main Results:

  • Diclofenac significantly prolonged skin bleeding time compared to baseline.
  • In vitro platelet aggregation was reduced in patients who received diclofenac.
  • No significant changes in bleeding time or platelet aggregation were observed in the control group.

Conclusions:

  • Diclofenac administration affects primary hemostasis by prolonging bleeding time.
  • Diclofenac impairs platelet aggregation, indicating an impact on platelet function.
  • These findings suggest careful consideration of diclofenac use in patients with potential bleeding risks.